Pheromone signalling and polarized morphogenesis in yeast

Curr Opin Genet Dev. 1997 Feb;7(1):59-66. doi: 10.1016/s0959-437x(97)80110-4.


Yeast cells respond to mating pheromones by activating a signal transduction pathway involving a seven transmembrane receptor/G protein complex linked to a mitogen-activated protein kinase module. Regulation of the G protein signal is controlled by the receptor and Sst2p; Sst2p may function as a GTPase-activating protein for the G protein alpha subunit. The Ste20 kinase acts in the linkage between the G protein and the MAP kinase module. Experiments suggest that binding of the Rho-like GTPase Cdc42p to Ste20p is not required for the mating response, yet is needed for the pseudohyphal growth response which involves many of the same kinases.

Publication types

  • Review

MeSH terms

  • GTP-Binding Proteins / physiology
  • Pheromones / physiology*
  • Saccharomyces cerevisiae / growth & development*
  • Signal Transduction / physiology*


  • Pheromones
  • GTP-Binding Proteins