Blockade of K(ATP) channels with glibenclamide does not abolish preconditioning during demand ischemia

Am J Cardiol. 1997 Jan 1;79(1):75-8. doi: 10.1016/s0002-9149(96)00681-9.


The role of adenosine triphosphate-sensitive potassium channels in the adaptive response to demand ischemia was tested in 22 patients treated with placebo or glibenclamide before sequential exercise testing or atrial pacing. Glibenclamide did not affect the improvement in signs of ischemia in both protocols, indicating that opening of these channels is not a mechanism of this adaptive response in humans.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adaptation, Physiological
  • Adenosine Triphosphate / pharmacology
  • Aged
  • Cardiac Pacing, Artificial
  • Double-Blind Method
  • Electrocardiography
  • Exercise Test
  • Female
  • Glyburide / pharmacology*
  • Humans
  • Hypoglycemic Agents / pharmacology*
  • Male
  • Middle Aged
  • Myocardial Ischemia / physiopathology*
  • Potassium Channels / drug effects
  • Potassium Channels / physiology*


  • Hypoglycemic Agents
  • Potassium Channels
  • Adenosine Triphosphate
  • Glyburide