The authors describe a case of nonparasitic splenic cyst treated by laparoscopic fenestration. The patient complained of left upper quadrant pain that increased during the prior 3 months. Computed tomography scan revealed a large cyst of the inferior pole of the spleen. The patient was submitted to laparoscopic wide fenestration of the cystic wall. The postoperative course was unremarkable and the patient was discharged with complete relief of symptoms. Laparoscopic technique provides the same results in terms of effectiveness and safety as traditional surgery, linked to the benefits of the mininvasive approach; thus, the laparoscopic fenestration can be considered the ideal treatment of nonparasitic splenic cysts.