Abstract
Stress-protective effect of phosphonglycerid and acyl analogs of neurotransmitter amino acids, which displayed nootropic activity was obtained. These compounds exerted positive influence on behavioral failure and morphological statement after 18-h immobilization. Dilithium-N-acetyl-L-aspartic acid (AKF-94) and di(3-dimethoxyphosphorylpropyl) ester of N-acetyl-DL-aspartic acid (PIR-87-6-0) displayed the most expressive activity. Previously activating influence of these compounds at excitatory amino acid transmission had been shown. We supposed participation of this way in stress-protective effect of new compounds.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adrenal Glands / drug effects
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Adrenal Glands / pathology
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Animals
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Anti-Anxiety Agents / therapeutic use
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / therapeutic use
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Diazepam / therapeutic use
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Drug Evaluation, Preclinical
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Male
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Motor Activity / drug effects
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Nootropic Agents / therapeutic use*
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Piracetam / therapeutic use
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Rats
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Restraint, Physical
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Stress, Psychological / pathology
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Stress, Psychological / physiopathology
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Stress, Psychological / prevention & control*
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Time Factors
Substances
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Anti-Anxiety Agents
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N-acetylaspartic acid di(3-dimethoxyphosphorylpropyl) ester
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Nootropic Agents
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Aspartic Acid
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Diazepam
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Piracetam