Bone resorption inhibitors from hop extract

H Tobe; Y Muraki; K Kitamura; O Komiyama; Y Sato; T Sugioka; H B Maruyama; E Matsuda; M Nagai

doi:10.1271/bbb.61.158

Bone resorption inhibitors from hop extract

Biosci Biotechnol Biochem. 1997 Jan;61(1):158-9. doi: 10.1271/bbb.61.158.

Authors

H Tobe¹, Y Muraki, K Kitamura, O Komiyama, Y Sato, T Sugioka, H B Maruyama, E Matsuda, M Nagai

Affiliation

¹ Pharma Research and Development Division, Hoechst Japan Limited, Saitama, Japan.

PMID: 9028043
DOI: 10.1271/bbb.61.158

Abstract

We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC50 (concentration of 50% inhibition) value was 5.9 x 10(-9)M.

MeSH terms

Bone Resorption / drug therapy*
Cyclohexenes
Dose-Response Relationship, Drug
Flavonoids
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Plants, Edible / chemistry*
Propiophenones / chemistry
Propiophenones / pharmacology*
Structure-Activity Relationship
Terpenes / chemistry
Terpenes / pharmacology

Substances

Cyclohexenes
Flavonoids
Plant Extracts
Propiophenones
Terpenes
humulon
xanthohumol