Vitamin E modifies neither fructosamine nor HbA1c levels in poorly controlled diabetes

Rev Invest Clin. Nov-Dec 1996;48(6):421-4.


Objective: To examine the effects of vitamin E on total serum protein glycation (fructosamine), hemoglobin glycation (HbA1c), and serum levels of glucose, total cholesterol, triglycerides, LDL-C, HDL-C, apolipoprotein A1 and apolipoprotein B.

Material and methods: Sixty poorly controlled diabetic patients were randomly assigned to receive either 1200 mg/day of vitamin E or identical placebo capsules during a two month period following a double blind cross-over design with a four week wash-out period between regimens.

Results: Seven patients were excluded from the study because of reasons not related to the medication. In the remaining 53 patients, the levels of serum glucose, fructosamine, HbA1c, total cholesterol, HDL-C, LDL-C, Apo A1 and Apo B did not vary significantly with vitamin E as compared with placebo.

Conclusions: No significant effects of vitamin E on any of the parameters evaluated were observed in poorly controlled diabetic patients.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Blood Glucose / analysis
  • Cross-Over Studies
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / drug therapy*
  • Double-Blind Method
  • Female
  • Fructosamine / blood*
  • Glycated Hemoglobin A / analysis*
  • Humans
  • Lipoproteins / blood
  • Male
  • Middle Aged
  • Triglycerides / blood
  • Vitamin E / pharmacology
  • Vitamin E / therapeutic use*


  • Blood Glucose
  • Glycated Hemoglobin A
  • Lipoproteins
  • Triglycerides
  • Vitamin E
  • Fructosamine