A preliminary study of possible psychoactive effects of intravenous forskolin in depressed and schizophrenic patients. Short communication

J Neural Transm (Vienna). 1996;103(12):1463-7. doi: 10.1007/BF01271261.


Forskolin is a unique activator of adenylate cyclase that bypasses membrane receptors and directly raised levels of the second messenger cyclic AMP. Depressed patients and schizophrenic patients with negative symptoms have been reported to have reduced cyclic AMP levels. In the first study of forskolin in psychiatry, we gave iv forskolin in a 75 minute infusion to four depressed and five schizophrenic patients. All four depressed patients showed a transient mood elevation or stimulation, as did two of the five schizophrenic patients.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antidepressive Agents / therapeutic use*
  • Colforsin / therapeutic use*
  • Depression / drug therapy*
  • Electrocardiography / drug effects
  • Female
  • Humans
  • Male
  • Schizophrenia / drug therapy*


  • Antidepressive Agents
  • Colforsin