Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Jan 15;184(2):177-83.
doi: 10.1016/s0378-1119(96)00592-6.

Cloning and Characterization of Chinese Hamster p53 cDNA

Affiliations

Cloning and Characterization of Chinese Hamster p53 cDNA

H Lee et al. Gene. .

Abstract

We have cloned and sequenced Chinese hamster p53 cDNA and have compared the p53 sequence in different Chinese hamster cell lines to several relevant phenotypes. Our results indicate that a mutation in CHO cells that changes Thr211 to Lys211 abrogates the ability to arrest in G1 and apparently renders cells capable of amplifying DNA. However, this mutation has no effect on the G2 checkpoint or on acute down-regulation of DNA replication after a radiation challenge.

Similar articles

See all similar articles

Cited by 11 articles

See all "Cited by" articles

Publication types

Substances

Associated data

LinkOut - more resources

Feedback