Nucleation mechanisms in protein folding

Curr Opin Struct Biol. 1997 Feb;7(1):3-9. doi: 10.1016/s0959-440x(97)80002-4.


Experiment and theory are converging on the importance of nucleation mechanisms in protein folding. These mechanisms do not use classic nuclei, which are well formed elements of structure present in ground states, but they use diffuse, extended regions, which are observed in transition states.

Publication types

  • Review

MeSH terms

  • Kinetics
  • Protein Conformation
  • Protein Folding*