Abstract
The crystal structure of integration host factor (IHF) complexed with DNA shows how a small heterodimeric protein can induce a big bend in DNA. IHF exerts leverage in the minor groove and wraps DNA around the body of the protein, providing another example of sequence-specific recognition of the minor groove.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins / chemistry
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Bacterial Proteins / metabolism*
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DNA, Bacterial / chemistry*
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DNA, Bacterial / metabolism
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / metabolism*
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Integration Host Factors
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Models, Molecular
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Molecular Sequence Data
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Nucleic Acid Conformation*
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Protein Binding
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Protein Conformation
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Sequence Alignment
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Sequence Homology, Amino Acid
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Structure-Activity Relationship
Substances
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Bacterial Proteins
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DNA, Bacterial
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DNA-Binding Proteins
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Integration Host Factors
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histone-like protein HU, bacteria