Not just another Fab: the crystal structure of a TcR-MHC-peptide complex

Structure. 1997 Feb 15;5(2):159-63. doi: 10.1016/s0969-2126(97)00175-5.

Abstract

The structure of a ternary complex formed between a T-cell receptor, a major histocompatibility complex (MHC) protein and a viral peptide provides new insights into the cellular immune response. The results provide a molecular basis for understanding the development of T cells and the reactions leading to transplant rejection and autoimmunity.

Publication types

  • Review

MeSH terms

  • Gene Products, tax / chemistry*
  • Gene Products, tax / immunology
  • Gene Products, tax / metabolism
  • HLA-A2 Antigen / chemistry*
  • HLA-A2 Antigen / immunology
  • HLA-A2 Antigen / metabolism
  • Humans
  • Infant, Newborn
  • Macromolecular Substances
  • Models, Molecular
  • Protein Binding
  • Protein Conformation*
  • Receptors, Antigen, T-Cell, alpha-beta / chemistry*
  • Receptors, Antigen, T-Cell, alpha-beta / immunology
  • Receptors, Antigen, T-Cell, alpha-beta / metabolism
  • Substrate Specificity

Substances

  • Gene Products, tax
  • HLA-A2 Antigen
  • Macromolecular Substances
  • Receptors, Antigen, T-Cell, alpha-beta