Abstract
The region downstream of the enhancer (DEN) of the long terminal repeat of the mink cell focus-forming murine leukemia virus is important for viral pathogenicity. Another important activity of DEN is its control of transcription in activated T cells, and we have determined that an NF-kappaB site is critical for this activity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Gene Expression Regulation, Viral*
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Humans
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Ionomycin / pharmacology
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Jurkat Cells
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Lymphocyte Activation
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Mink Cell Focus-Inducing Viruses / genetics*
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Mink Cell Focus-Inducing Viruses / pathogenicity
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Mutagenesis
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NF-kappa B / metabolism
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Regulatory Sequences, Nucleic Acid*
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Repetitive Sequences, Nucleic Acid*
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T-Lymphocytes / drug effects
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T-Lymphocytes / metabolism*
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Tetradecanoylphorbol Acetate / pharmacology
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Transcription, Genetic*
Substances
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NF-kappa B
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Ionomycin
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Tetradecanoylphorbol Acetate