Identification of nucleotide sequences that regulate transcription of the MCF13 murine leukemia virus long terminal repeat in activated T cells

J Virol. 1997 Mar;71(3):2572-6. doi: 10.1128/JVI.71.3.2572-2576.1997.

Abstract

The region downstream of the enhancer (DEN) of the long terminal repeat of the mink cell focus-forming murine leukemia virus is important for viral pathogenicity. Another important activity of DEN is its control of transcription in activated T cells, and we have determined that an NF-kappaB site is critical for this activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Gene Expression Regulation, Viral*
  • Humans
  • Ionomycin / pharmacology
  • Jurkat Cells
  • Lymphocyte Activation
  • Mink Cell Focus-Inducing Viruses / genetics*
  • Mink Cell Focus-Inducing Viruses / pathogenicity
  • Mutagenesis
  • NF-kappa B / metabolism
  • Regulatory Sequences, Nucleic Acid*
  • Repetitive Sequences, Nucleic Acid*
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / metabolism*
  • Tetradecanoylphorbol Acetate / pharmacology
  • Transcription, Genetic*

Substances

  • NF-kappa B
  • Ionomycin
  • Tetradecanoylphorbol Acetate