No evidence for an allelic association between schizophrenia and markers D22S278 and D22S283

Am J Med Genet. 1997 Feb 21;74(1):37-9. doi: 10.1002/(sici)1096-8628(19970221)74:1<37::aid-ajmg8>3.0.co;2-s.

Abstract

We report a case control association study using markers D22S278 and D22S283 in 90 unrelated patients with DSMIII-R schizophrenia and 90 controls matched for ethnicity, age and sex. No differences between allele frequencies for either marker were observed when the two groups were compared (D22S278: chi 2 = 6.53, df = 7, P = 0.51; D22S283: chi 2 = 14.73, df = 15, P = 0.48). These findings fail to support previous work by others suggesting the presence of allelic association between the markers D22S278 and D22S283 and schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Case-Control Studies
  • Chromosomes, Human, Pair 22*
  • Female
  • Genetic Linkage
  • Genetic Markers*
  • Genotype
  • Humans
  • Male
  • Matched-Pair Analysis
  • Middle Aged
  • Polymerase Chain Reaction
  • Schizophrenia / genetics*

Substances

  • Genetic Markers