Strategic proposals for predicting drug-drug interactions during new drug development: based on sixteen deaths caused by interactions of the new antiviral sorivudine with 5-fluorouracil prodrugs

J Toxicol Sci. 1996 Dec;21(5):299-300. doi: 10.2131/jts.21.5_299.
No abstract available

MeSH terms

  • Animals
  • Antiviral Agents / adverse effects*
  • Arabinofuranosyluracil / adverse effects
  • Arabinofuranosyluracil / analogs & derivatives*
  • Drug Design*
  • Drug Interactions
  • Drug Therapy, Combination
  • Fluorouracil / adverse effects*
  • Herpes Zoster / drug therapy
  • Humans
  • Japan
  • Prodrugs / adverse effects*
  • Rats
  • Risk Assessment

Substances

  • Antiviral Agents
  • Prodrugs
  • Arabinofuranosyluracil
  • sorivudine
  • Fluorouracil