Resistance to UV-irradiation of DNA synthesis in fibroblast cell lines derived from LEC strain rats

J Vet Med Sci. 1997 Jan;59(1):67-9. doi: 10.1292/jvms.59.67.


After UV-irradiation, no difference in the survival curves was observed among cell lines derived from LEC strain (LEC) rats and WKAH strain (WKAH) rats. The dose-response curves for inhibition of DNA synthesis in WKAH-derived cells showed a sharp decline at lower doses and a mild decline at higher doses of UV-rays. In contrast, the dose-response curves in LEC-derived cell lines had no sharp component, and were almost identical to the mild component of the curves in WKAH-derived cells. These results show that DNA synthesis in the cell lines of LEC rats was more resistant to UV-irradiation than that of WKAH rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Cell Survival / radiation effects*
  • DNA / biosynthesis*
  • DNA / radiation effects
  • DNA Replication / radiation effects*
  • Dose-Response Relationship, Radiation
  • Fibroblasts / cytology
  • Fibroblasts / radiation effects
  • Rats
  • Rats, Inbred Strains
  • Ultraviolet Rays*


  • DNA