Expression of neurotrophins and their receptors in the developing and adult rat adrenal gland

Brain Res Mol Brain Res. 1996 Dec 31;43(1-2):351-5. doi: 10.1016/s0169-328x(96)00243-4.


We have studied the postnatal expression of neurotrophins, their cognate high-affinity trk receptors and the low-affinity NGF receptor (p75LNGFR) in the rat adrenal gland using RT-PCR. Neurotrophin mRNAs were detectable during the whole postnatal period. Strongest signals were obtained for BDNF and NT4/5. Expression of trkA, trkB, trkC and p75LNGFR was found at all ages studied. Signals for trkA were highest in the adult adrenal medulla, whereas signals for p75LNGFR were highest in the adult adrenal cortex. Cur data suggest still largely enigmatic roles for neurotrophins in functions of the adrenal medulla and possibly also the cortex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Glands / growth & development
  • Adrenal Glands / metabolism*
  • Animals
  • Brain-Derived Neurotrophic Factor / metabolism*
  • Rats
  • Rats, Wistar
  • Receptors, Nerve Growth Factor / metabolism*


  • Brain-Derived Neurotrophic Factor
  • Receptors, Nerve Growth Factor