Caudal hindbrain neuromedin B-preferring receptors participate in the control of food intake

Am J Physiol. 1997 Jan;272(1 Pt 2):R433-7. doi: 10.1152/ajpregu.1997.272.1.R433.

Abstract

Recent studies have identified two subtypes of bombesin (BN) receptors in the rat central nervous system: gastrin releasing-peptide (GRP) preferring and neuromedin B (NMB) preferring. To investigate a role for the NMB-preferring receptor subtype in feeding suppression elicited by fourth ventricular (4V) BN administration, we evaluated the ability of a selective NMB-preferring receptor antagonist, BIM-23127, to block suppression of glucose intake produced by 4V BN (10 pmol). Our results showed that 4V administration of BIM-23127 dose dependently antagonized the suppression of glucose intake produced by 4V BN. In addition, 4V administration of BIM-23127 alone increased glucose intake above that observed in the baseline condition. These results support a role for the NMB-preferring BN receptor subtype in the suppression of intake produced by 4V BN administration and suggest that endogenously released NMB participates in ingestive control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bombesin / pharmacology
  • Dose-Response Relationship, Drug
  • Drinking / drug effects
  • Eating / drug effects
  • Eating / physiology*
  • Glucose
  • Injections, Intraventricular
  • Male
  • Peptides, Cyclic / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Bombesin / physiology*
  • Rhombencephalon / metabolism*
  • Solutions

Substances

  • BIM 23127
  • Peptides, Cyclic
  • Receptors, Bombesin
  • Solutions
  • Glucose
  • Bombesin