Contrast-enhanced MR imaging in the evaluation of treatment response and prediction of outcome in multiple sclerosis

J Magn Reson Imaging. 1997 Jan-Feb;7(1):29-37. doi: 10.1002/jmri.1880070106.


MR imaging is becoming increasingly important in the evaluation of multiple sclerosis based on its sensitivity to acute, often subclinical events in the brain and because it provides a basis for measuring the accumulation of disease over time. Contrast-enhanced MR imaging in particular evaluates disease at the fundamental level of events affecting the blood-brain barrier. This review emphasizes (a) recent developments in the use of contrast-enhanced MR imaging as a measure of disease in patient groups and individuals and (b) its emerging role in evaluating new therapies.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Animals
  • Clinical Trials as Topic
  • Contrast Media*
  • Evaluation Studies as Topic
  • Humans
  • Image Enhancement / methods*
  • Magnetic Resonance Imaging / methods*
  • Multiple Sclerosis / diagnosis*
  • Multiple Sclerosis / drug therapy
  • Multiple Sclerosis / pathology
  • Optic Nerve / pathology
  • Predictive Value of Tests
  • Prognosis
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Spinal Cord / pathology
  • Treatment Outcome


  • Adrenal Cortex Hormones
  • Contrast Media