Ferumoxides and Tc-99m sulfur colloid: comparison of the tumor-to-liver uptake in focal nodular hyperplasia

J Magn Reson Imaging. 1997 Jan-Feb;7(1):125-9. doi: 10.1002/jmri.1880070117.

Abstract

The tumor-to-liver uptake of two reticuloendothelial agents, namely ferumoxides and technetium-99m (Tc-99m) sulfur colloid, was compared in focal nodular hyperplasia (FNH). Twelve patients with FNH who had undergone ferumoxides-enhanced MR imaging and planar Tc-99m sulfur colloid scintigraphy within 1 year were included from the study. Fourteen patients with FNH with a diameter larger than 3 cm were selected for the comparison. The tumor-to-liver ferumoxides uptake was calculated and the Tc-99m sulfur colloid uptake was assessed visually. Fermuoxides uptake was observed in all but one patient with FNH (mean tumor-to-liver ratio = .36). The six tumors showing normal (n = 5) or increased (n = 1) radiocolloid uptake when compared to the liver accumulated more ferumoxides than the eight tumors showing decreased radiocolloid uptake (P < .01). However, in some tumors, no direct relation was observed between ferumoxides and Tc-99m sulfur colloid uptake. Our observations suggest that ferumoxides uptake might not exactly mimic Tc-99m sulfur colloid uptake in FNH.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Contrast Media / pharmacokinetics*
  • Dextrans
  • Diagnosis, Differential
  • Female
  • Ferrosoferric Oxide
  • Humans
  • Hyperplasia / diagnosis
  • Image Enhancement / methods
  • Iron / pharmacokinetics*
  • Liver / metabolism*
  • Liver Diseases / diagnosis*
  • Liver Diseases / metabolism
  • Magnetic Resonance Imaging / methods*
  • Magnetite Nanoparticles
  • Male
  • Middle Aged
  • Oxides / pharmacokinetics*
  • Sensitivity and Specificity
  • Technetium / pharmacokinetics*

Substances

  • Contrast Media
  • Dextrans
  • Magnetite Nanoparticles
  • Oxides
  • Technetium
  • Iron
  • ferumoxides
  • Ferrosoferric Oxide