Dual dynamic contrast-enhanced MR imaging

J Magn Reson Imaging. Jan-Feb 1997;7(1):230-5. doi: 10.1002/jmri.1880070136.


A method was devised for obtaining dynamic contrast-enhanced T1-weighted and relaxation rate (delta R2*) images simultaneously to evaluate regional hemodynamics of the brain tumors. On a 1.5-T MR system, dual dynamic contrast-enhanced images were obtained using a gradient echo (dual echo fast field echo) pulse sequence with the keyhole technique to improve temporal and spatial resolution during a rapid bolus injection of gadopentetate dimeglumine. The dynamic T1 contrast images were obtained from the first echo: moreover. integral delta R2*dt values were calculated from the first and the second echo images. The dynamic T1 contrast images provided information about characteristic enhancement pattern (vascularization and disruption of blood-brain barrier), and the integral delta R2*dt values provided a map of regional blood pool in tumor site, peritumoral edema, and other surrounding regions of the brain. The ability to obtain dynamic contrast-enhanced T1 contrast and delta R2* imaging at the same time allows optimization of the advantages of each and thereby more information about the microvascular circulation of the brain lesions.

MeSH terms

  • Brain / pathology*
  • Brain Neoplasms / blood supply
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / pathology
  • Contrast Media
  • Diagnosis, Differential
  • Hemodynamics
  • Humans
  • Image Enhancement / methods*
  • Magnetic Resonance Angiography / methods
  • Magnetic Resonance Imaging / methods*
  • Sensitivity and Specificity
  • Spinal Cord Neoplasms / blood supply
  • Spinal Cord Neoplasms / diagnosis*
  • Spinal Cord Neoplasms / pathology


  • Contrast Media