Regulation of transcription of MHC class II genes

Curr Opin Immunol. 1997 Feb;9(1):107-13. doi: 10.1016/s0952-7915(97)80166-5.


Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is responsible for the control of class II expression and the regulation of expression by interferon-gamma.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Gene Expression Regulation / immunology*
  • Genes, MHC Class II / immunology*
  • Humans
  • Transcription, Genetic / immunology*