Genes and lineages in the formation of the enteric nervous system

Curr Opin Neurobiol. 1997 Feb;7(1):101-9. doi: 10.1016/s0959-4388(97)80127-4.


The enteric nervous system is large, complex, and independent of the CNS. Its neural-crest-derived precursors migrate along defined pathways to colonize the bowel. Recent studies of the sequential actions of essential growth and transcription factors have revealed that enteric neuronal development involves a complex interaction of lineage-determined and microenvironmental elements.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Line
  • Embryo, Mammalian / physiology
  • Embryo, Nonmammalian
  • Embryonic and Fetal Development
  • Genes*
  • Intestines / embryology*
  • Intestines / innervation*
  • Nervous System / embryology
  • Neural Crest / physiology
  • Stem Cells / physiology