Basic helix-loop-helix genes in neural development

Curr Opin Neurobiol. 1997 Feb;7(1):13-20. doi: 10.1016/s0959-4388(97)80115-8.


Several major advances in the understanding of the regulation of vertebrate neurogenesis by members of the basic helix-loop-helix (bHLH) protein family have been made in the past year. Specifically, a number of bHLH genes have been cloned and shown to convert non-neuronal fate to neuronal fate when expressed ectopically. In particular, studies on NeuroD and Neurogenin suggest a regulatory pathway, providing powerful molecular tools to study vertebrate neurogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics
  • Drosophila
  • Embryonic and Fetal Development
  • Genes*
  • Helix-Loop-Helix Motifs / genetics*
  • Nervous System / embryology*