Chemokines: Leucocyte Recruitment and Activation Cytokines

Lancet. 1997 Feb 15;349(9050):490-5. doi: 10.1016/s0140-6736(96)07524-1.

Abstract

Chemokines are a family of structurally related proteins that share the ability to induce migration of specific subsets of leucocytes. These specialised cytokines play a critical part in the generation of cellular inflammation, both in the protective responses to invading pathogens and in the pathological processes associated with infection and immune-mediated diseases. Chemokines are more than simple chemotactic factors, since they are also implicated in leucocyte activation, angiogenesis, and antimicrobial functions, including a protective role in HIV infection. These molecules provide potentially valuable targets for therapeutic intervention in a wide range of diseases.

MeSH terms

  • Chemokines / physiology*
  • Chemotactic Factors / physiology
  • Chemotaxis, Leukocyte / physiology
  • Cytokines / physiology
  • HIV Infections / immunology
  • Humans
  • Inflammation Mediators / physiology
  • Leukocytes / immunology
  • Leukocytes / physiology*

Substances

  • Chemokines
  • Chemotactic Factors
  • Cytokines
  • Inflammation Mediators