Quantitative sensory testing has become commonplace in clinical neurophysiology units. Measurement of the thermal and vibratory senses provides an estimate on function of sensory small and large fibers, respectively. Being psychophysical parameters, sensory threshold values are not objective, and various test algorithms have been developed aiming at optimized results. In this review the various test algorithms are screened, and their relative advantages and disadvantages are discussed. Considerations of quality control are reviewed, and the main fields of clinical application are described.