Development and preliminary validation of a pain measure specific to neuropathic pain: the Neuropathic Pain Scale

Neurology. 1997 Feb;48(2):332-8. doi: 10.1212/wnl.48.2.332.


Neuropathic pain syndromes are commonly seen in clinical practice and are frequently used as pain models in testing new therapies. However, no pain scale exists with the primary purpose to measure pain in neuropathic syndromes. This paper describes the development and preliminary validation of the Neuropathic Pain Scale (NPS), which is designed to assess distinct pain qualities associated with neuropathic pain. Results support the discriminant and predictive validity of the NPS items. Moreover, the NPS items appear to be sensitive to treatments known to impact neuropathic pain. These findings provide support for the further development of the NPS.

MeSH terms

  • Diabetic Neuropathies / complications
  • Diabetic Neuropathies / physiopathology
  • Herpesviridae Infections / complications*
  • Humans
  • Neuralgia / complications*
  • Neuralgia / physiopathology*
  • Pain / etiology*
  • Pain Measurement*
  • Peripheral Nerve Injuries
  • Reflex Sympathetic Dystrophy / complications*
  • Reflex Sympathetic Dystrophy / physiopathology*
  • Reproducibility of Results