Immunogenicity of influenza vaccine (1993-94 winter season) in HIV-seropositive and -seronegative ex-intravenous drug users

Vaccine. 1997 Jan;15(1):97-102. doi: 10.1016/s0264-410x(96)00057-6.


The humoral response (haemagglutination inhibiting antibodies) to trivalent split influenza vaccine for the 1993-94 winter season (A/Beijing/32/92 (H3N2), A/Singapore/6/86 (H1N1) and B/Panama/45/90) was evaluated in a group of young HIV-seropositive ex-intravenous heroin users and compared with responses measured in HIV-seronegative individuals with a similar history. HIV-negative volunteers showed an overall positive response suggesting that previous heroin use did not influence their humoral response to influenza vaccine. Comparable results were obtained in HIV-positive subjects with CD4+ lymphocyte counts > 500 microliters-1, whereas impaired reactivity was found in HIV-positive volunteers with CD4+ counts < 500 microliters-1. Booster vaccination did not increase antibody levels in any of the groups studied, although the data did not exclude a positive influence of a second vaccine dose on persistence of antibody at 120 days after the first dose. No significant changes were observed in p24 antigenemia levels in HIV-positive individuals after vaccination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Viral / biosynthesis
  • CD4 Lymphocyte Count
  • Female
  • HIV Antibodies / blood
  • HIV Core Protein p24 / blood
  • HIV Infections / complications
  • HIV Infections / immunology*
  • HIV Seronegativity / immunology*
  • Humans
  • Immunization, Secondary
  • Influenza Vaccines / immunology*
  • Male
  • Middle Aged
  • Substance Abuse, Intravenous / complications*


  • Antibodies, Viral
  • HIV Antibodies
  • HIV Core Protein p24
  • Influenza Vaccines