Strains of methicillin-resistant Staphylococcus aureus (MRSA) have become increasingly common in the United States and in many other countries since 1975. The prevalence of MRSA colonization and infection has increased in acute-care and chronic-care facilities, outpatient clinics, and in the community. We reviewed the sensitivity test of antibiotics in Chang Gung Memorial Hospital system, and revealed a steady decrease in sensitivity to Cephalothin, Oxacillin and Clindamycin during the past 10 years. It is still sensitive to Vancomycin. However, the amount of Vancomycin prescribed in the hospital system has increased three-folds during the recent 4 years. The purpose of this article is to review the MRSA in this hospital and to describe measures used to control MRSA transmission.