The source of urinary nitrosamines in patients with enterocystoplasties

Br J Urol. 1997 Jan;79(1):28-31. doi: 10.1046/j.1464-410x.1997.02686.x.


Objective: To assess the factors influencing urinary nitrosamine production in patients with enterocystoplasties.

Patients, subjects and methods: The study comprised 100 patients with an enterocystoplasty, 20 patients with interstitial cystitis, 30 with infective cystitis and 120 control subjects drawn from hospital staff and out-patients. Urinary nitrosamine levels were measured and the urine samples cultured for microorganisms.

Results: Nitrosamine levels were significantly higher only in patients with enterocystoplasties who also had higher urinary white cell counts or significant bacteriuria.

Conclusion: Patients with an enterocystoplasty and significant bacteriuria are most at risk from potential nitrosamine-induced epithelial injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteriuria / urine
  • Cystitis / microbiology
  • Cystitis / urine*
  • Cystitis, Interstitial / urine
  • Humans
  • Leukocyte Count
  • Nitrosamines / urine*
  • Urinary Diversion*
  • Urinary Tract Infections / urine*


  • Nitrosamines