An investigation of polymorphism in the interleukin-10 gene promoter

Eur J Immunogenet. 1997 Feb;24(1):1-8. doi: 10.1111/j.1365-2370.1997.tb00001.x.


Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Cytokines / genetics
  • Gene Expression Regulation / immunology
  • Gene Frequency / immunology
  • Humans
  • Interleukin-10 / biosynthesis
  • Interleukin-10 / genetics*
  • Lymphocytes
  • Molecular Sequence Data
  • Polymorphism, Genetic / immunology*
  • Promoter Regions, Genetic / immunology*
  • Sequence Analysis, DNA


  • Cytokines
  • Interleukin-10

Associated data

  • GENBANK/U63015