Novel Transferable Beta-Lactam Resistance With Cephalosporinase Characteristics in Salmonella Enteritidis

J Antimicrob Chemother. 1997 Jan;39(1):85-7. doi: 10.1093/jac/39.1.85.

Abstract

An isolate of Salmonella enteritidis was found to produce a plasmid-encoded beta-lactamase (DHA-1) that conferred resistance to extended-spectrum cephalosporins and cephamycins. The substrate and inhibition profiles of this enzyme resemble a class C beta-lactamase. This is the first report of a plasmid-mediated cephalosporinase of this class in the Salmonella genus.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Cephalosporinase / metabolism*
  • Clavulanic Acid
  • Clavulanic Acids / pharmacology
  • Conjugation, Genetic
  • DNA, Bacterial / genetics
  • DNA, Bacterial / metabolism
  • Enzyme Inhibitors / pharmacology
  • Gene Transfer Techniques
  • Humans
  • Microbial Sensitivity Tests
  • Middle Aged
  • Plasmids
  • Salmonella enteritidis / drug effects
  • Salmonella enteritidis / enzymology*
  • Salmonella enteritidis / genetics
  • beta-Lactam Resistance / genetics*
  • beta-Lactamase Inhibitors

Substances

  • Anti-Bacterial Agents
  • Clavulanic Acids
  • DNA, Bacterial
  • Enzyme Inhibitors
  • beta-Lactamase Inhibitors
  • Clavulanic Acid
  • Cephalosporinase