Abstract
By determining the beta-lactam susceptibility of Enterobacteriaceae isolated in Eastern Romania from 1985 to 1993, three Escherichia coli, three Salmonella typhimurium and one Klebsiella pneumoniae isolates with reduced susceptibility to co-amoxiclav were found. The antibiotic susceptibility of the isolates and their E. coli derivatives, and kinetic values suggested the following resistance mechanisms: hyperproduction of TEM in S. typhimurium, limited antibiotic uptake in K. pneumoniae and OXA production in one strain of E. coli. Despite a normal beta-lactamase activity, the two remaining E. coli strains and their derivatives were less susceptible to co-amoxiclav.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amoxicillin / pharmacology
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Amoxicillin-Potassium Clavulanate Combination
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Clavulanic Acids / pharmacology
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Drug Therapy, Combination / pharmacology*
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Escherichia coli / drug effects*
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Escherichia coli / enzymology
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Escherichia coli / genetics
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Escherichia coli Infections / microbiology
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Humans
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Isoelectric Focusing
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / enzymology
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Klebsiella pneumoniae / genetics
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Microbial Sensitivity Tests
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Plasmids
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Romania
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Salmonella Infections / microbiology
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Salmonella typhimurium / drug effects*
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Salmonella typhimurium / enzymology
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Salmonella typhimurium / genetics
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beta-Lactamases / analysis
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beta-Lactamases / metabolism
Substances
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Clavulanic Acids
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Amoxicillin-Potassium Clavulanate Combination
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Amoxicillin
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beta-Lactamases