Wnt signalling goes nuclear

Bioessays. 1997 Feb;19(2):101-4. doi: 10.1002/bies.950190204.

Abstract

The Wnt signalling cascade is a highly conserved signalling pathway throughout the animal kingdom. In Xenopus, Wnt signalling functions in mesodermal dorsoventral patterning. Earlier work on deciphering the components of the wnt signalling cascade left a gap between cytosolic beta-catenin, the final member of the cascade, and the nuclear target genes. Several recent papers now reveal how the Wnt signal is transmitted into the nucleus. Surprisingly, beta-catenin directly interacts with the transcription factor LEF-1/XTCF-3, and thereby is not only translocated into the nucleus but also modulates the properties of LEF-1/XTCF-3 as a transcription factor.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Nucleus / physiology
  • Cytoskeletal Proteins / physiology
  • Drosophila
  • Proteins / physiology*
  • Signal Transduction*
  • Trans-Activators*
  • Transcription Factors / physiology
  • Wnt Proteins
  • Wnt-5a Protein
  • Xenopus
  • Xenopus Proteins*
  • beta Catenin

Substances

  • CTNNB1 protein, Xenopus
  • Cytoskeletal Proteins
  • Proteins
  • Trans-Activators
  • Transcription Factors
  • Wnt Proteins
  • Wnt-5a Protein
  • Wnt5a protein, Xenopus
  • Xenopus Proteins
  • beta Catenin