Mechanism of gene expression by the glucocorticoid receptor: role of protein-protein interactions

Bioessays. 1997 Feb;19(2):153-60. doi: 10.1002/bies.950190210.

Abstract

The glucocorticoid receptor belongs to an important class of transcription factors that alter the expression of target genes in response to a specific hormone signal. The glucocorticoid receptor can function at least at three levels: (1) recruitment of the general transcription machinery; (2) modulation of transcription factor action, independent of DNA binding, through direct protein-protein interactions; and (3) modulation of chromatin structure to allow the assembly of other gene regulatory proteins and/or the general transcription machinery on the DNA. This review will focus on the multifaceted nature of protein-protein interactions involving the glucocorticoid receptor and basal transcription factors, coactivators and other transcription factors, occurring at these different levels of regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Gene Expression Regulation*
  • Humans
  • Molecular Sequence Data
  • Protein Binding
  • Receptors, Glucocorticoid / physiology*
  • Signal Transduction*

Substances

  • Receptors, Glucocorticoid