misshapen encodes a protein kinase involved in cell shape control in Drosophila

Gene. 1997 Feb 20;186(1):119-25. doi: 10.1016/s0378-1119(96)00694-4.


We have identified a novel protein kinase encoded by the misshapen gene, which is required for the normal shape and orientation of Drosophila photoreceptor cells. misshapen is also expressed in the embryonic mesoderm, pole plasm and other sites of cell shape change or movement. We propose that msn may act in a signal transduction pathway leading to cytoskeletal re-arrangements.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Movement / genetics*
  • Drosophila / embryology*
  • Drosophila / genetics*
  • Embryo, Nonmammalian / cytology
  • Embryonic and Fetal Development / genetics
  • Eye / embryology*
  • Eye / pathology
  • Gene Expression Regulation, Developmental
  • Molecular Sequence Data
  • Photoreceptor Cells, Invertebrate / pathology
  • Protein Kinases / biosynthesis
  • Protein Kinases / genetics*
  • Protein Kinases / physiology
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Transcription, Genetic


  • Protein Kinases