Finally! The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG

Immunol Res. 1997 Feb;16(1):29-57. doi: 10.1007/BF02786322.


F. W. Rogers Brambell was the father of the field of transmission of immunity, which he entered 50 years before the present era. As part of his quantitative and temporal studies on transmission, he defined the first Fc receptor system for IgG, and furthermore recognized the link between transmission of passive immunity from mother to young and protection from catabolism for IgG. This article provides a historical overview of the efforts of Professor Brambell and summarizes the subsequent elaboration of the details of the physiology and molecular biology of this remarkable receptor system.

Publication types

  • Biography
  • Historical Article
  • Portrait
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Allergy and Immunology / history*
  • Animals
  • Biological Transport / immunology
  • Endothelium, Vascular / immunology
  • Endothelium, Vascular / metabolism
  • History, 20th Century
  • Humans
  • Immunity, Maternally-Acquired
  • Immunoglobulin G / history
  • Immunoglobulin G / immunology*
  • Mice
  • Rabbits
  • Receptors, Fc / history
  • Receptors, Fc / immunology*
  • Receptors, Fc / physiology
  • Receptors, IgG / immunology*
  • Receptors, IgG / physiology


  • Immunoglobulin G
  • Receptors, Fc
  • Receptors, IgG

Personal name as subject

  • F W Brambell