Abstract
ERM (ezrin/radixin/moesin) proteins crosslink actin filaments with plasma membranes. The carboxyl termini of these proteins bind actin filaments, while the amino termini bind plasma membranes using a binding partner, such as CD44. Specific signals activate ERM proteins to bind actin filaments and the plasma membrane; these include phosphoinositides and/or phosphorylation mechanisms, which might be located downstream from the Rho-dependent pathway.
MeSH terms
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Actins / metabolism*
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Animals
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Cell Membrane / metabolism
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Cytoskeletal Proteins*
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Cytoskeleton / metabolism
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DNA-Binding Proteins / metabolism*
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Membrane Proteins / metabolism
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Neuropeptides*
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Phylogeny
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Rho Factor / metabolism
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Signal Transduction
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Transcription Factors / metabolism*
Substances
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Actins
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Cytoskeletal Proteins
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DNA-Binding Proteins
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Membrane Proteins
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Neuropeptides
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Rho Factor
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Transcription Factors
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erythrocyte membrane band 4.1 protein
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erythrocyte membrane protein band 4.1-like 1