ERM proteins: head-to-tail regulation of actin-plasma membrane interaction

Trends Biochem Sci. 1997 Feb;22(2):53-8. doi: 10.1016/s0968-0004(96)10071-2.


ERM (ezrin/radixin/moesin) proteins crosslink actin filaments with plasma membranes. The carboxyl termini of these proteins bind actin filaments, while the amino termini bind plasma membranes using a binding partner, such as CD44. Specific signals activate ERM proteins to bind actin filaments and the plasma membrane; these include phosphoinositides and/or phosphorylation mechanisms, which might be located downstream from the Rho-dependent pathway.

Publication types

  • Review

MeSH terms

  • Actins / metabolism*
  • Animals
  • Cell Membrane / metabolism
  • Cytoskeletal Proteins*
  • Cytoskeleton / metabolism
  • DNA-Binding Proteins / metabolism*
  • Membrane Proteins / metabolism
  • Neuropeptides*
  • Phylogeny
  • Rho Factor / metabolism
  • Signal Transduction
  • Transcription Factors / metabolism*


  • Actins
  • Cytoskeletal Proteins
  • DNA-Binding Proteins
  • Membrane Proteins
  • Neuropeptides
  • Rho Factor
  • Transcription Factors
  • erythrocyte membrane band 4.1 protein
  • erythrocyte membrane protein band 4.1-like 1