Uric Acid-Related Nephrolithiasis

Urol Clin North Am. 1997 Feb;24(1):135-48. doi: 10.1016/s0094-0143(05)70359-1.


Abnormalities in uric acid metabolism are associated with uric acid and calcium oxalate urolithiasis. Clinical stone formation depends on multiple identifiable risk factors that affect uric acid and calcium oxalate solubility. The understanding of urinary pH is critical to direct appropriate treatment of uric acid-related nephrolithiasis. Understanding uric acid metabolism and the pathophysiology of uric acid and calcium oxalate stone formation leads to a rational treatment approach to uric acid and hyperuricosuric calcium oxalate stone disease.

Publication types

  • Review

MeSH terms

  • Calcium / metabolism
  • Calcium Oxalate
  • Humans
  • Kidney / metabolism
  • Kidney Calculi / chemistry
  • Kidney Calculi / diagnosis
  • Kidney Calculi / etiology*
  • Kidney Calculi / therapy
  • Uric Acid / metabolism*


  • Calcium Oxalate
  • Uric Acid
  • Calcium