Abstract
A cDNA clone encoding the Na+, K(+)-Atpase gamma-subunit polypeptide was cloned from a human fetal liver cDNA library. The deduced amino acid sequence of the protein comprised 58 amino acids with a calculated molecular weight of 6400 Da, and showed about 86% homology when compared with those of the bovine, rat and mouse Na+, K(+)-ATPase gamma-subunits published elsewhere. Northern blot analysis showed that the cDNA hybridized to a 0.7 kb mRNA which was expressed in human kidney, pancreas and fetal liver.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cattle
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Cloning, Molecular
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DNA, Complementary / genetics*
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Fetus / metabolism
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Humans
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Kidney / metabolism
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Liver / metabolism
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Mice
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Molecular Sequence Data
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Molecular Weight
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Pancreas / metabolism
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Protein Conformation
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Rats
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Sequence Homology, Amino Acid
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Sodium-Potassium-Exchanging ATPase / chemistry
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Sodium-Potassium-Exchanging ATPase / genetics*
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Tissue Distribution
Substances
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DNA, Complementary
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RNA, Messenger
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Sodium-Potassium-Exchanging ATPase