Plasma lipoproteins and incidence of non-insulin-dependent diabetes mellitus in Pima Indians: protective effect of HDL cholesterol in women

Atherosclerosis. 1997 Jan 3;128(1):113-9. doi: 10.1016/s0021-9150(96)05978-3.

Abstract

The role of plasma lipoproteins in the development of non-insulin-dependent diabetes mellitus (NIDDM) was studied in 787 non-diabetic (2-h glucose < 11.1 mmol/l) Pima Indians (265 men and 522 women). Subjects were followed for a mean of 9.8 (range: 1.8-16.4) years, during which 261 (76 men and 185 women) developed NIDDM. In men and women, very-low-density lipoprotein (VLDL) cholesterol, VLDL triglyceride, low-density lipoprotein triglyceride and total triglyceride, controlled for age, predicted NIDDM (P < 0.01 for each). These effects diminished when controlled for age, sex, body mass index, systolic blood pressure and 2-h glucose. However, high-density lipoprotein (HDL) cholesterol, controlled for age, body mass index, systolic blood pressure and 2-h glucose, was a significant protective factor for NIDDM in women (hazard rate ratio (HRR) = 0.35, 95% CI (0.23-0.54), P < 0.001, 90th compared with 10th percentile) but not in men (HRR = 1.04, 95% CI (0.53-2.05), P = 0.915). This association remained significant in women when controlled for fasting or 2-h plasma insulin concentrations, other estimates of insulin resistance or alcohol consumption. The protective effect of HDL cholesterol was similar among women with normal (2-h glucose < 7.8 mmol/1) or impaired (7.8 mmol/l < or = 2-h glucose < 11.1 mmol/l) glucose tolerance at baseline. These results indicate that lipoprotein disorders are an early accompaniment of the abnormalities that lead to NIDDM.

MeSH terms

  • Adult
  • Arizona
  • Blood Glucose / analysis
  • Blood Pressure
  • Body Mass Index
  • Cholesterol, HDL / blood*
  • Cholesterol, VLDL / blood
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / ethnology*
  • Female
  • Humans
  • Indians, North American*
  • Insulin / blood
  • Insulin Resistance
  • Lipoproteins / blood*
  • Lipoproteins, LDL / blood
  • Lipoproteins, VLDL / blood
  • Male
  • Proportional Hazards Models
  • Risk Factors
  • Triglycerides / blood

Substances

  • Blood Glucose
  • Cholesterol, HDL
  • Cholesterol, VLDL
  • Insulin
  • Lipoproteins
  • Lipoproteins, LDL
  • Lipoproteins, VLDL
  • Triglycerides
  • low density lipoprotein triglyceride
  • very low density lipoprotein triglyceride