Allogeneic bone marrow transplant for chronic myelogenous leukemia in a patient with multiple sclerosis

Bone Marrow Transplant. 1997 Feb;19(4):395-7. doi: 10.1038/sj.bmt.1700666.


Multiple sclerosis (MS) is a demyelinating disease of the central nervous system in which immune mechanisms appear to be an important component of the pathophysiology. Although the clinical manifestations are variable, a subset of patients develops a progressive clinical course associated with marked neurologic impairment and significant morbidity. BMT has been proposed as treatment for such patients based on preclinical data as well as clinical observations in other autoimmune diseases. We report clinical and MRI findings in an MS patient, later diagnosed with CML, and treated with an allogeneic BMT.

Publication types

  • Case Reports

MeSH terms

  • Bone Marrow Transplantation*
  • Female
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy*
  • Magnetic Resonance Imaging
  • Middle Aged
  • Multiple Sclerosis / complications*
  • Multiple Sclerosis / pathology
  • Transplantation, Homologous