Cell proliferation, cell loss and expression of bcl-2 and p53 in human pulmonary neoplasms

Br J Cancer. 1997;75(4):545-7. doi: 10.1038/bjc.1997.95.


Immunohistochemical staining of bcl-2 and p53 proteins was compared with thymidine labelling index (TLI) and cell loss factor (O) in lung cancer. Neither bcl-2 nor p53 overexpression was associated with high cell loss but strong bcl-2 staining was associated with higher TLI. Concomitant strong p53 and bcl-2 expression, not the usual inverse relationship, plus high cell-loss factor was present in three neuroendocrine carcinomas. Other factors presumably have a role in controlling cell death in these tumours.

MeSH terms

  • Apoptosis*
  • Carcinoma, Bronchogenic / metabolism*
  • Carcinoma, Bronchogenic / pathology*
  • Cell Division
  • Humans
  • Lung Neoplasms / metabolism*
  • Lung Neoplasms / pathology*
  • Neoplasm Proteins / metabolism*
  • Proto-Oncogene Proteins c-bcl-2 / metabolism*
  • Tumor Suppressor Protein p53 / metabolism*


  • Neoplasm Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Tumor Suppressor Protein p53