An endothelial receptor for oxidized low-density lipoprotein

Nature. 1997 Mar 6;386(6620):73-7. doi: 10.1038/386073a0.


Endothelial dysfunction or activation elicited by oxidatively modified low-density lipoprotein (Ox-LDL) has been implicated in the pathogenesis of atherosclerosis, characterized by intimal thickening and lipid deposition in the arteries. Ox-LDL and its lipid constituents impair endothelial production of nitric oxide, and induce the endothelial expression of leukocyte adhesion molecules and smooth-muscle growth factors, which may be involved in atherogenesis. Vascular endothelial cells in culture and in vivo internalize and degrade Ox-LDL through a putative receptor-mediated pathway that does not involve macrophage scavenger receptors. Here we report the molecular cloning, using expression cloning strategy, of an Ox-LDL receptor from vascular endothelial cells. The cloned receptor is a membrane protein that belongs structurally to the C-type lectin family, and is expressed in vivo in vascular endothelium and vascular-rich organs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blotting, Northern
  • CHO Cells
  • Cattle
  • Cell Line
  • Cloning, Molecular
  • Conserved Sequence
  • Cricetinae
  • DNA, Complementary
  • Endothelium, Vascular / metabolism*
  • Humans
  • Lectins / genetics
  • Lectins / metabolism
  • Lipoproteins, LDL / metabolism*
  • Molecular Sequence Data
  • Oxidation-Reduction
  • Receptors, LDL / genetics
  • Receptors, LDL / metabolism*
  • Receptors, Oxidized LDL
  • Scavenger Receptors, Class E
  • Sequence Homology, Amino Acid
  • Transfection


  • DNA, Complementary
  • Lectins
  • Lipoproteins, LDL
  • OLR1 protein, human
  • Receptors, LDL
  • Receptors, Oxidized LDL
  • Scavenger Receptors, Class E
  • oxidized low density lipoprotein

Associated data

  • GENBANK/AB010710
  • GENBANK/D89049