Learning without performance in PKC-deficient Drosophila

Neuron. 1997 Feb;18(2):307-14. doi: 10.1016/s0896-6273(00)80270-6.


The performance of a task is often assumed to be a prerequisite for the learning of many tasks, including the associative conditioning of courtship in the fruit fly, Drosophila melanogaster. Transgenic flies specifically inhibited for the enzyme protein kinase C dissociate the acquisition of learning and memory from performance of the task. They fail to show immediate suppression of courtship but nonetheless develop normal memory of it.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Conditioning, Psychological / physiology*
  • Drosophila melanogaster
  • Female
  • Learning / physiology*
  • Locomotion / physiology
  • Male
  • Memory / physiology*
  • Protein Kinase C / deficiency
  • Protein Kinase C / physiology*
  • Retention, Psychology / physiology
  • Sexual Behavior, Animal / physiology*
  • Smell / physiology


  • Protein Kinase C