Fusarium keratitis following the use of topical antibiotic-corticosteroid therapy in traumatised eyes

Ann Acad Med Singap. 1996 Nov;25(6):862-5.

Abstract

Keratomycosis is a rare sight-threatening infection of the cornea. Important predisposing factors in its pathogenesis include corneal trauma and use of topical corticosteroid or antibiotic-corticosteroid therapy. Some family physicians are unaware of the dangers of unmonitored topical corticosteroid therapy for traumatised eyes. Three cases of Fusarium keratitis following the use of topical antibiotic-corticosteroid therapy in traumatised eyes are reported. Despite aggressive anti-fungal therapy, one eye required a therapeutic penetrating keratoplasty for impending corneal perforation, another eye progressed to corneal perforation and required evisceration while the third eye developed endophthalmitis which also required evisceration. The potential danger of fungal infections of the cornea following the unmonitored use of topical antibiotic-corticosteroids in traumatised eyes is highlighted.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage
  • Adrenal Cortex Hormones / adverse effects*
  • Adult
  • Aged
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects*
  • Corneal Diseases / drug therapy*
  • Corneal Diseases / etiology
  • Corneal Injuries*
  • Corneal Transplantation
  • Drug Therapy, Combination
  • Eye Evisceration
  • Eye Infections, Fungal / chemically induced*
  • Eye Infections, Fungal / microbiology
  • Eye Infections, Fungal / surgery
  • Fusarium / isolation & purification*
  • Humans
  • Keratitis / chemically induced*
  • Keratitis / microbiology
  • Keratitis / surgery
  • Male
  • Middle Aged

Substances

  • Adrenal Cortex Hormones
  • Anti-Bacterial Agents