Overexpression of intercellular adhesion molecule-1 (ICAM-1) in pancreatic adenocarcinoma in comparison with normal pancreas

Pancreas. 1997 Mar;14(2):181-6. doi: 10.1097/00006676-199703000-00011.


To elucidate the role of intercellular adhesion molecules (ICAMs), which has not been well understood in pancreas, we investigated the localization and expression of ICAM-1 by immunohistochemistry and in situ hybridization (ISH) in pancreatic adenocarcinoma and in normal pancreas. The localizations of ICAM-2 and ICAM-3 were also investigated by immunohistochemistry. In normal pancreas, acinar cells, duct epithelial cells, and Langerhans islet cells failed to stain with anti-ICAM-1, anti-ICAM-2, and anti-ICAM-3 antibodies. These cells showed no expression of ICAM-1 mRNA. On the other hand, various percentages of carcinoma cells were stained with anti-ICAM-1 antibody, while no carcinoma cells were stained with anti-ICAM-2 and anti-ICAM-3 antibodies. ICAM-1 mRNA expression was also observed in carcinoma cells, and ICAM-1 mRNA expression was associated with localization of the ICAM-1 protein. These results suggest that ICAM-1 expression is up-regulated in pancreatic adenocarcinoma cells and that ICAM-1 is involved in malignant processes in pancreas.

MeSH terms

  • Adenocarcinoma / chemistry
  • Adenocarcinoma / metabolism*
  • Antigens, CD / analysis
  • Antigens, Differentiation*
  • Cell Adhesion Molecules / analysis
  • DNA Probes
  • Gene Expression*
  • Humans
  • Immunoenzyme Techniques
  • In Situ Hybridization
  • Intercellular Adhesion Molecule-1 / analysis*
  • Intercellular Adhesion Molecule-1 / genetics*
  • Pancreas / chemistry
  • Pancreas / metabolism*
  • Pancreatic Neoplasms / chemistry
  • Pancreatic Neoplasms / metabolism*
  • RNA, Messenger / analysis


  • Antigens, CD
  • Antigens, Differentiation
  • Cell Adhesion Molecules
  • DNA Probes
  • ICAM2 protein, human
  • ICAM3 protein, human
  • RNA, Messenger
  • Intercellular Adhesion Molecule-1