Cellular environments and apoptosis: tissue microenvironments control activated T-cell death

Immunol Today. 1997 Feb;18(2):72-6. doi: 10.1016/s0167-5699(97)01003-7.


Activated T cells must be removed by apoptosis at the end of an immune response in order to maintain cellular homeostasis. Although recent attention has focused on the role of CD95 (Fas/APO-1) in the elimination of activated T cells, apoptosis can also be induced by cytokine deprivation. Here, Arne Akbar and Mike Salmon describe how both death pathways interact in activated T cells and are profoundly influenced by different tissue microenvironments.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / immunology*
  • Humans
  • Lymphocyte Activation*
  • T-Lymphocytes / immunology*
  • Tissue Distribution / immunology