Implications for Immunosurveillance of Altered HLA Class I Phenotypes in Human Tumours

Immunol Today. 1997 Feb;18(2):89-95. doi: 10.1016/s0167-5699(96)10075-x.

Abstract

HLA class I downregulation is a frequent event associated with tumour invasion and development. Altered HLA class I tumour phenotypes can have profound effects on T-cell and natural killer (NK)-cell antitumour responses. Here, Federico Garrido and colleagues analyse these altered tumour phenotypes in detail, indicating their potential relevance for implementation of immunotherapeutic protocols and strategies to overcome tumour escape mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • HLA Antigens / classification*
  • Histocompatibility Antigens Class I / classification*
  • Humans
  • Immunologic Surveillance*
  • Immunophenotyping*
  • Neoplasms / immunology*

Substances

  • HLA Antigens
  • Histocompatibility Antigens Class I