The ethical boundaries of drug research in pediatrics

Pediatr Clin North Am. 1997 Feb;44(1):27-40. doi: 10.1016/s0031-3955(05)70461-2.


Research abuses in the pediatric setting, mistakes, regulation, minimal investment, and professional misconceptions may contribute to children becoming therapeutic orphans. The moral imperative to expand pediatric pharmacology is urgent but the enterprise is not without risk. Pediatricians as experts in child care are privileged to be able to advocate for the expansion of this invaluable research while simultaneously advocating for the children who are to be involved. In the development of ethical drug research, children's well-being and empowerment can be realized. A shared commitment will help to ensure that in the future we will be better able to provide safe and effective medication and so greatly enhance the care of children.

Publication types

  • Review

MeSH terms

  • Brain Death
  • Child
  • Child Advocacy
  • Drug Evaluation*
  • Ethics Committees
  • Ethics, Medical*
  • Humans
  • Information Dissemination
  • Informed Consent
  • Nontherapeutic Human Experimentation
  • Parental Consent
  • Pediatrics*
  • Persons
  • Research*
  • Risk Assessment*
  • Terminal Care
  • Therapeutic Human Experimentation
  • Vulnerable Populations