Predictors of the rate of renal function decline in non-insulin-dependent diabetes mellitus

Am J Nephrol. 1997;17(1):59-67. doi: 10.1159/000169073.


A multivariate analysis of 263 Mexican-American, African-American, and Non-Hispanic white non-insulin-dependent diabetes mellitus patients with end-stage renal disease revealed that in subjects following a linear course of decline of renal function, Mexican-American ethnicity (p = 0.0503) and female sex (p = 0.0036) hasten the rate of decline of renal function, while age (p = 0.0004), hypertension duration (p = 0.0058), and diabetes duration (p = 0.0587) slow the rate of decline of renal function. Blood pressure and glycemic control do not predict the rate of decline. These data suggest that ethnicity and sex-related factors may be as important as blood pressure and glycemic control during the course of non-insulin-dependent diabetic nephropathy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • African Continental Ancestry Group
  • Age Factors
  • Cohort Studies
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / ethnology*
  • Diabetic Nephropathies / ethnology*
  • Disease Progression
  • European Continental Ancestry Group
  • Female
  • Humans
  • Hypertension / ethnology
  • Kidney Failure, Chronic / ethnology*
  • Kidney Failure, Chronic / etiology
  • Male
  • Mexican Americans
  • Middle Aged
  • Multivariate Analysis
  • Risk Factors
  • Sex Factors